DOI: 10.21276/ajptr
Fri, 22 Mar 2019

Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Betamethasone Sodium Phosphate and Ofloxacin in their Combined Dosage form

Priya Varshney*1, Dhara Patel1, Sharav Desai2, Dhanajay Meshram1

1.Department of Quality Assurance, Pioneer Pharmacy Degree College, Vadodara-390019

2. Department of pharmaceutical Microbiology and biotechnology, Pioneer Pharmacy Degree College, Vadodara-390019 


A simple, sensitive, precise, accurate and economic Q-absorption ratio method for the quantitative determination of betamethasone sodium phosphate and ofloxacin in bulk and combined dosage form has been developed and validated. Q absorption ratio method uses the ratio of absorbances at two selected wavelengths, one which is iso-absorptive point and other being the λ-max of one of the two components. Betamethasone sodium phosphate and ofloxacin shows an iso-absorptive point at 247nm in methanol, the second wavelength used was 289nm, which is λ-max of ofloxacin. The linearity was obtained in the concentration range of 2-12 ug/ml for both the drugs in distilled water. The proposed method is recommended for routine analysis. The results of analysis have been validated statistically and by recovery studies.

Keywords: Betamethasone sodium phosphate, Ofloxacin, Q-absorption ratio method, Validation.

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