DOI: 10.21276/ajptr
Fri, 22 Mar 2019

Antioxidant activity of Methanolic fruit extract of Morinda Tinctoria Roxb in Cerebral Ischemia Induced by Bilateral Common Carotid artery occlusion in rats.

Anand M1*, Muralidharan P2

1. Department of pharmacology and Toxicology, NRI-panchakarma, Cheruthuruthy post, Thrissur, Kerala – 679531. India.

2. Dept. of Pharmacology & Toxicology, C.L.Baid Metha College of Pharmacy, OMR, Throipakkam, Chennai – 600097, India


The present study was designed to investigate te antioxidant activity oof methanolic extract of Morinda Tinctoria Roxb against (MEMT) fruits in the cerebral ischemia induced animal model system.  Global cerebral ischemia was induced by temporary bilateral common carotid  artery occlusion for 15 min followed by reperfusion in Sprague Dawley Rats  and the animals were pre-treated with MEMT (200 and 400 mg kg-1) for 1 week before induction. After induction of ischemia by BCCAO animals were again treated with MEMT for 1 week and the animals were sacrificed. Homogenized content of brain were estimated in control, sham and treatment groups. The MEMT showed the significance of p<0.01 done by ANOVA and Dunetts in the levels of antioxidants such as superoxide dismutase, glutathione peroxidase, glutathione reductase, lipid peroxidation, catalase, protein levels, vitamin C levels. At the 1 week after ischemia a maximum of 85% protection of neurons in CA1 region showed in treatment group at the dose 400 mg kg-1. The results showed neuroprotective nature of MEMT and protection may be due to reduction of oxidative stress which occurs by alteration in levels of antioxidants and MEMT has the potential to use in treatment of global ischemia.

Keywords: Morinda tinctoria, bilateral common carotid artery occlusion, antioxidants, CA1

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