Mon, 20 Nov 2017

Synthesis, Characterization and Microbial assay of some novel S-hepta-O-acetyl maltosyl-1-aryl dithiocarbamates

Varsha S. Zade1, Shirish P. Deshmukh1*

1.P. G. Department of Chemistry, Shri Shivaji College, Akola-444003 (M. S.) India


ABSTRACT

Carbohydrate science has been extensively studied and many excellent reviews are available. N and S-linked derivatives of various sugars have received a great attention because of their vital role in several biological processes. Ureas, thioureas and their derivatives have strong antibacterial, antitumor activities. They also play an important role in organic synthesis as intermediates. This considerable attention has been directed towards the synthesis of various thiomaltosides. A series of S-hepta-O-acetyl maltosyl-1-aryl dithiocarbamates have been synthesized by the interaction of hepta-O-acetyl maltosyl bromide and various ammonium aryl dithiocarbamates in isopropanolic medium. The newly synthesized compounds have been characterized by analytical and IR, 1H NMR and Mass spectral analysis. The polarimetric study of the compounds has been carried out. Antibacterial and antifungal activities of these compounds were determined on E. coli, S. aureus, Ps. aeruginosa, S. typhi, R. oligosporus and A. niger. These compounds show appreciable activity towards these microorganisms.

Keywords: Maltosyl bromide, ammonium aryl dithiocarbamates, maltosyl aryl dithiocarbamates, Microbial assay.


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