Mon, 20 Nov 2017

Formulation and Evaluation of Floating Matrix Tablet of Pantoprazole Sodium Sesquihydrate

Ashish Kumar Garg1*, Saurabh Gupta1, Anuja Bharadwaj1, Rajesh Kumar2

1.Akal College of Pharmacy and Technical Education, Sangrur, Punjab (India)

2.Rayat-Bahra Institute of Pharmacy, Hoshiarpur, Punjab (India)


ABSTRACT

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Pantoprazole sodium sesquihydrate as a model drug and to optimize its drug release profile. Pantoprazole sodium tablets were prepared by direct compression technique. Formulations contained Xanthan gum, PVP K30 and gas generating agent such as sodium bicarbonate and citric acid were taken as independent variables. The physical parameters of the tablets were characterized and were found within the limits. By comparing dissolution profiles of different formulations, the formulation F5 was considered as a better formulation. The drug release from all the formulations was found to follow zero order kinetics and Peppas modeling. The diffusion exponent of formulations was found (n<0.89) to have non-fickian (anomalous) diffusion mechanism. The tablets eroded upon contact with the release medium, and the relative importance of drug diffusion, polymer swelling and tablet erosion for the resulting release patterns varied significantly with the type of matrix former

Keywords : Floating tablet, Pantoprazole sodium sesquihydrate, PVP K30, Xanthan gum


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