Tue, 21 Nov 2017

Synthesis of 4-(2-Alkyl/Aryl Benzimidazolo N-1-Yl-Methyl) 7-Hydroxy Coumarins

S P Shahare1*, V N Ingle2, L J Paliwal2

1.Dr. Ira Nimdeokar P.G. & Research centre for Chemistry Hislop College, Nagpur-440001

2.P.G.T.D. of Chemistry, RTM Nagpur University, Nagpur-440033


ABSTRACT

The synthesis of a number of 4-(2’-alkyl/aryl benzimidazolo N-1-yl-methyl) -7 hydroxycoumarins containing pharmacophores of the coumarin and benzimidazole in a single molecule has been achieved.  4-Chloromethyl coumarins is used as N-alkylating (N-alkylation of benzimidazole) agent which is prepared by Pechmann condensation. 2-Substituted benzimidazoles were prepared by interaction of carboxylic acids and o-phenylenediamine. The structures of synthesized compounds have been assigned on the basis of chemical tests, IR, 1H NMR, and Mass spectral data.

Keywords: 4-Chloromethyl coumarin, 7-hydroxy coumarin, N-alkylation, benzimidazole.


[PDF]  Viewed: 691  Downloaded: 119
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter