DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Synthesis of 4-(2-Alkyl/Aryl Benzimidazolo N-1-Yl-Methyl) 7-Hydroxy Coumarins

S P Shahare1*, V N Ingle2, L J Paliwal2

1.Dr. Ira Nimdeokar P.G. & Research centre for Chemistry Hislop College, Nagpur-440001

2.P.G.T.D. of Chemistry, RTM Nagpur University, Nagpur-440033


The synthesis of a number of 4-(2’-alkyl/aryl benzimidazolo N-1-yl-methyl) -7 hydroxycoumarins containing pharmacophores of the coumarin and benzimidazole in a single molecule has been achieved.  4-Chloromethyl coumarins is used as N-alkylating (N-alkylation of benzimidazole) agent which is prepared by Pechmann condensation. 2-Substituted benzimidazoles were prepared by interaction of carboxylic acids and o-phenylenediamine. The structures of synthesized compounds have been assigned on the basis of chemical tests, IR, 1H NMR, and Mass spectral data.

Keywords: 4-Chloromethyl coumarin, 7-hydroxy coumarin, N-alkylation, benzimidazole.

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