Mon, 20 Nov 2017

Study of Nitrofurantoin Susceptibility in Urinary Isolates of E.coli A Need to Revert Back to Older Drugs

Raminder Sandhu1*, Kanwardeep Singh2, Gaurav Sharma3

1. Department of Microbiology, BPS Govt. Medical College for Women, Sonepat (Haryana), India.

2. Department of Microbiology, Govt. Medical College, Amritsar (Punjab), India

3. Department of Forensic Medicine, BPS Govt. Medical College for Women, Sonepat(Haryana), India.


ABSTRACT

Urinary tract infections have a high incidence in general population, with potential complications and constantly shifting trends in drug resistance that emphasizes the importance of selecting appropriate antimicrobial therapy. The present study shall focus on nitrofurantoin susceptibility in urinary E.coli isolates which heralds shifting trends in drug resistance among uropathogens and emphasizes on the need to revert back to older urinary antimicrobial agents. The study shall serve as an update on the susceptibility of E.coli to various commonly used antibiotics. A retrospective study was conducted by analyzing culture results and antimicrobial susceptibility pattern of E.coli isolated from 4533 urine samples collected from both inpatients and outpatients in Microbiology Department of tertiary care institute from January 2013 to December 2013. E.coli isolates depicted maximum sensitivity to Nitrofurantoin (87.12%) followed by Amikacin (86.53%) and Gentamicin (68.19%) whereas resistance remained high to Cefazolin (86.82%), Norfloxacin (84.53%), Cotrimoxazole (82.23%), Amoxyclav (82.23%) and Ciprofloxacin (76.22%). Nitrofurantoin susceptibility of E.coli isolates remained high in females (90.61%) as compared to males (83.09%). Among inpatients maximum sensitivity to nitrofurantoin was exhibited by isolates recovered from Gynae/obstetrics ward (94.59%) followed by pediatrics ward (82.35%). The study depicts promising use of Nitrofurantoin as narrow spectrum antibiotic to de-escalate the selection pressure and as fluoroquinolones sparing drug in areas where Cotrimoxazole resistance remains high in the uncomplicated cystitis. Clinicians should use local surveillance data to formulate empiric selection of antibiotic therapy in urinary tract infections.

Keywords: Nitrofurantoin, UTI, antimicrobialsusceptibility


[PDF]  Viewed: 994  Downloaded: 109
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter