Tue, 21 Nov 2017

UV-Spectrophotometric Determination of Maraviroc in Bulk and Pharmaceutical Dosage Form

Mastanamma.Shaik1*, Haritha Kondayigunta1, P.Saidulu1, D.Sindu Priya1.

1. Department of pharmaceutical Analysis, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, GUNTUR, Andhra Pradesh, India-522510


ABSTRACT

The present work describes three simple, precise and economical UVmethods have been developed for the estimation of Maraviroc in bulk and pharmaceutical dosage form. Method A shown the absorbance maxima at 217 nm, method B area under curve method which involves the calculation of integrated value of absorbance with respect to the wavelength between two selected wavelength 212 -222 nm respectively. and in the first order derivative spectra showed sharp peak at 248 nm for method C. The developed methods were founded to be linear in the concentration range of 10-100 µg/ml. The developed methods were validated by following the analytical performance parameters suggested by ICH. All the validation parameters were within the acceptable range. As economical solvent is used, these methods were used for routine analysis of Maraviroc in bulk and pharmaceutical formulation.

Key words: Absorption Maxima, Area under curve, Derivative Spectroscopy, Maraviroc, Maraviroc Tablet Dosageform.


[PDF]  Viewed: 725  Downloaded: 82
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter