Mon, 20 Nov 2017

Association of Erythrocyte Sedimentation Rateto White Blood Corpuscles and Liver Enzymes

Rajeswari S1, Anila Mathan2,Swaminathan S3*

1. Research Scholar, Department of Biochemistry, Vels University, Pallavaram Chennai 600117

2.Senior Consultant and Head, Department of Haematology& Transfusion Medicine, Apollo Specialty Hospitals Ayanambakkam, Chennai 600 095

3.Senior Consultant and Head,  Department of Biochemistry, Apollo Specialty Hospitals, Ayanambakkam, Chennai 600 095


ABSTRACT

Studies carried out in the past have shown that in infectious diseases there is increase in the levels of Erythrocyte Sedimentation Rate (ESR), White Blood Corpuscles (WBC) and liver enzymes Alanine Aminotransferase (ALT), Gamma GlutamylTransferase (GGT) and Lactate Dehydrogenase (LDH).  There are other inflammatory markers like C reactive protein (CRP) and Procalcitonin, both of which are altered in several infectious diseases.  This study is an attempt to find out the correlation of ESR  to WBC and  several analytes of liver function tests such as  Aspartate aminotransferase (AST), ALT,  ALP,  GGT and  Albumin.  Results available for 100 patients attending the master health check up were used to find out the above associations. Very good correlations were observed between ESR and WBC for all patients (p<0.0001) and males  & females (p<0.01).  When the results for ESR was grouped as normal and abnormal, ESR showed association to ALT,AST and ALP (p<0.05) for normal patients and to only WBC for abnormal patients (p<0.05).  The results obtained in this study confirms that ESR results always correlates with WBC and to some extend to liver function tests like ALT,AST and ALP and GGT. Further studies are required using a large number of patients and to extend such studies to find out association of ESR to various inflammatory markers.

Keywords:ESR, WBC, ALT, AST, ALP and GGT


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