Mon, 20 Nov 2017

Synthesis, Characterization and Cytotoxic Activity of New Palladium Complexes with 3-Thiolanespiro-5-Hydantoin and 4-Thio-1h-Tetrahydropyranespiro-5-Hydantoin

Adriana GeorgievaBakalova*1, RossenTodorov Buyukliev1, AntoninaTzekova Nikolova1, GeorgiTzvetanov Momekov2

1. Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria,

2.Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria


ABSTRACT

Four Pd(II) and Pd(IV) complexes with 3-thiolanespiro-5’-hydantoin and 4-thio-1H-tetrahydropyranespiro-5’-hydantoin were synthesized. Thechemical structures of newcomplexes were studied by elemental analysis, IR, 1H, 13C NMR spectra. The spectroscopic investigation of new palladium complexes in comparison with the metal free ligands show that the bonding of the ligands with metal ions is realized through the sulfur atom from the S-containing saturated rings. This coordination mode is in accordance with the data obtained for the platinum complexes with the same ligands. The new complexes were investigated for cytotoxicity on panel of human tumor cell lines. The tested compounds exerted concentration-dependent cytotoxic effects against some of the tumor cell lines.

Keywords: Pd complexes, cytotoxicity, S-containing saturated rings


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