Mon, 20 Nov 2017

Formulation and Evaluation of Sublingual Tablets of Amlodipine Besylate Containing Beta-Cyclodextrin

Vankani Ankit K1*

1.Department of Pharmaceutics, Babaria Institute of Pharmacy, Vadodara - Mumbai, National Highway 8, Varnama, Gujarat 391240

 


ABSTRACT

Amlodipine Besylate is a molecule used in Hypertension and currently available in tablet dosage form. The objective of present study was to develop and evaluate Amlodipine Besylate intraoral sublingual formulation for faster release and absorption. Four formulations containing varying concentrations of Croscarmellose sodium and b-Cyclodextrin were formulated. Various evaluations like weight variation, % friability, Hardness, diameter, water absorption ratio, wetting time, disintegration time, drug content and calibration curve were performed. From the results, it was concluded that all batches pass the evaluation tests with F4 showing the fastest wetting and Disintegration. From the data of Dissolution studies it was concluded that formulation F4 showed highest drug release in 10 minutes. It can be concluded that sublingual tablets of Amlodipine Besylate will prove to be patient friendly.

Keywords: Amlodipine Besylate, Croscarmellose sodium, b-Cyclodextrin, sublingual

 

 


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