Mon, 18 Dec 2017

Experimental Models of Focal Ischemia: from Preference to Parameters

Samardeep singh1*

1.Department of pharmacology, I.S.F college of pharmacy, Moga-142001, Punjab, India


ABSTRACT

Focal ischemia, a ischemia of specific area of the brain, is responsible for many deaths and disabilities across the globe that may be due to clot formation or accidental collapse of arteries in either case treatment is required to treat ischemic insult and further deterioration of neurons in the brain. To know exact pathophysiology and biochemical events it becomes necessary to study those conditions in vivo. Furthermore to check drug moieties for the treatment of ischemic conditions and its prognosis, animal models are required to mimic those conditions artificially. There are many factors on which choice of animal for animal model is depend like age, species and genetics. The species which would be near to humans in evolution hierarchy should exhibit almost similar physiological as well as pathological architecture of vascularity and ischemic condition. But other factors cannot be ignored in this regard like finances, survival and labour intensiveness. During literature survey, out of many available models of ischemia, rodent models are found to be used mostly in preclinical research so this review is a collaborative approach contains methods and types to select animal and animal models along with the mechanisms and assessment of ischemic conditions.

Keywords: Focal Ischemia, MCAO, animal models, ischemia, choice of animal models


[PDF]  Viewed: 881  Downloaded: 89
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter