DOI: 10.21276/ajptr
Mon, 27 May 2019

Formulation and Evaluation of Phenytoin Loaded Biofilms using Annona Squamosa Biomaterial

Abhijeet Ojha1*, N.V. Satheesh Madhav2

1.Research Scholar, Uttarakhand Technical University, Dehradun

2.DIT University, Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun


In the present paper an effort was made to isolate a biomaterial from the fruit pulp of Annona squamosa and evaluate its film forming capacity. Annona squamosa was isolated by an economic method and subjected to various physical evaluation parameters. The biomaterial was subjected to spectral studies like IR, 1H NMR and DSC analyses. Phenytoin loaded biofilms were prepared using the isolated biomaterial and other co- processing agents. The prepared biofilms were evaluated for their film parameters and subjected to in-vitro drug release studies using static MS diffusion apparatus. The results were compared with the standard HPMC film. The experimental results revealed that the prepared biofilms possessed good folding endurance with appreciable release characteristics. The best film formulation was PS6 with percentage cumulative release of 91.85% over 36 hours. Hence it clearly indicated that the isolated biomaterial possessed inbuilt filmability.

Keywords: Biofilms, Biopolymers, Annona squamosa, Phenytoin.

[PDF]   Viewed: 1386   Downloaded: 122
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter