Mon, 18 Dec 2017

Evaluation of Wound Healing Activity of Piper Betle Leaves and Stem Extract In Experimental Wistar Rats

Kiran C Nilugal1*, Komathi Perumal2, Ugander R E1, Asif iqbal chittor3

1.School of pharmacy Asia Metropolitan University, G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia

2.School of biomedicine Asia Metropolitan University, G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia

3.Faculty of pharmacy, Masterskill global college, kuching, Sarawak,  Malaysia


ABSTRACT

The present work aims at evaluating the wound healing potential of a traditional plant Piper betle (PB) of both leaves and stem. The ethanolic extract of both Piper betle leaves and stem were investigated to evaluate the rate of wound healing enclosure and the histology of healed wounds in rats. Four groups of adult female albino wisttar rats were experimentally wounded at the dorsal region of the rats. Group 1 animals were left with untreated and set as negative control. Group 2 animals were treated with 10% Povidone Iodine, and set as positive control. Group 3 and 4 treated with ointment formulation containing 10% Piper betle leaves and 10% Piper betle stem leaves extract respectively. All the four groups are treated with for 21 days. Wound healing was assessed by rate of wound closure estimation and histology studies on the 21st day of post wounding. 10% Piper betle stem enhanced the wound healing process by increasing rate of wound closure compared to negative control group. Histological observation also showed better organized tissue and more collagen fibers in 10% Piper betle stem treated group. These results strongly document the significant effect of 10% Piper betle stem extract to accelerates the rate of wound healing and closure in the experimentally induced wound rats.

Keywords: Piper betle, Wound healing, Hematoxylin & Eosin stain and Massion Trichrome stain the rate of wound healing and closure in the experimentally induced wound rats.


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