DOI: 10.21276/ajptr
Mon, 27 May 2019

Microwave Initiated Synthesis of Pyrimidine Analogues and Study of their Antimicrobial Properties

Kundan Lal*1, L. J.Paliwal1, M.B.Bagade2

1.Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440 033, India.

2.Department of Chemistry, Seth Kesarimal Porwal College, Kamptee - 441 002, India


An efficient and convenient multi component reaction for the synthesis of 2-Imino-4,6-diaryldihydropyrimidines scaffolds have been accomplished from chalcones and guanidine hydrochloride in the presence of a catalytic amount of an alkali under solvent-free conditions using microwave irradiation.  The synthesized pyrimidines have been characterized on the basis of their chemical properties and spectroscopic data.  Operational simplicity, short reaction times, excellent yields and environmentally-benign conditions are the other advantages of this protocol. Using this method, we have synthesized some new pyrimidines with antimicrobial properties and high chemical yields in much short reaction times.

Keywords: Solvent- free, Antibacterial, Chalcones, Biological activity, Green Chemistry

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