Mon, 18 Dec 2017

Ultra-Violet Spectrophotometric Method for Validation of Rupatadine Fumarate from Bulk Drug and Pharmaceutical Formulation

Rele Rajan V*1, Tiwatane Prathamesh P1

1.Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai 400 016.


ABSTRACT

A simple, rapid, sensitive and precise UV spectrophotometric method has been developed for the estimation of rupatadine fumarate from bulk drug and pharmaceutical formulation. In this method rupatadine fumarate showed maximum absorbance at about 250 nm in absolute alcohol. Beer’s law was followed in the concentration range of 1 to 30 μg/ ml. Regression equation was found to be y = 0.0257- 3x 10-5  and coefficient of correlation was 0.9999 . The proposed method is accurate, sensitive, reproducible and useful for the estimation of   rupatadine fumarate from bulk drug and pharmaceutical formulation.

Keywords: Rupatadine fumarate, Absolute alcohol 


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