DOI: 10.21276/ajptr
Thu, 23 May 2019

Formulation and In-Vitro Evaluation of Oro-Dispersible Tablets of Olanzapine by Direct Compression

Minal Shantilal Chopda1*, Priya Rangari1, K. R. Khandelwal1, Mahesh Bhadgale1

1.Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune - 411033


The present research work was to design and develop an optimized oro-dispersible tablet dosage form of an anti-psychotic drug, Olanzapine by using direct compression technology.  Total number of nine formulations were prepared as per the standard experimental design protocol using Design Expert Software (Version 8.0.5, Stat-Ease, Inc.). Independent variables such as the amount of the amount of Crospovidone XL 10 (A) and the amount of Avicel PH 102 (B) were optimized by application of Response surface methodology using Central Composite Design. The dependent variables selected were in-vitro dispersion time and wetting time of the tablets. All the evaluated physical parameters of the oro-dispersible tablets were practically within control. The direct compression method used to prepare the oro-dispersible tablets in this study is relatively simple, safe and economic. A stable, effective and pleasant tasting mouth dissolving tablet, which has a good balance over all the physical parameters was formulated.

Keywords: Oro-dispersible, Superdisintegrants, Crospovidone, Response Surface Methodology.

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