Mon, 18 Dec 2017

Synthesis, cytotoxic activities and photophysical properties of 7-amino-4-methylcoumarin based 1,4-di substituted 1,2,3-triazole derivatives by “Click” chemistry

Harikrishna Nallapaneni1, Venkata Rao Chunduri1*

1. Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India


ABSTRACT

The present study will focus mainly on the new series of 1,2,3- triazoles linked with 7-amino-4-methyl coumarin (4) are synthesized using Click reaction. All the newly synthesized compounds (7a-q) are characterized by analytical and spectroscopic methods (IR, HRMS, 1H and 13C-NMR) and subjected to cytotoxicity screening against a panel of six different human cancer cell lines viz. Hela, PANC1, HepG2, SKNSH, MDAMB and IMR 32 cell lines. Interestingly, among the tested molecules, some of the analogs displayed better cytotoxic activity. Out of the synthesized triazoles (7a-q), compounds 7h, 7i and 7l showed potent activity, as 7h and 7l showed more potent activity against IMR32 cell line with GI50 of 0.015 and 0.02 μM, respectively and 7i with GI50 of 0.02 μM against SKNSH cell line. Further photophysical properties (UV & fluorescence) for these compounds (7a-q) are also discussed.

Keywords: 1,3-Dipolar cycloaddition, 1,2,3-Triazole, Cytotoxic & photophysical properties.


[PDF]  Viewed: 703  Downloaded: 244
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter