Mon, 18 Dec 2017

Anti-diabetic activity of Eugenia Operculata roxb. In streptozotocin induced diabetic mice

Yumnam Romila Devi1*, Pranab Behari Mazumder1

1. Department of Biotechnology, Assam university Silcher. Assam-788011, India


ABSTRACT

The anti-diabetic effect of aqueous and ethanol extract of leaves of Eugenia operculata Roxb. was evaluated in streptozotocin induced diabetic mice. Streptozotocin is a synthetic nitrosoureido glucopyranose derivative isolated from fermentations of Streptomyces acromogenes. STZ induced diabetes by selectively destroying the insulin producing β cells by inducing necrosis. Extract (250mg/kg b.w) was administered orally to albino mice both normal and diabetic for 21 days. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, change in body weight, liver glycogen content and serum lipid profile. In oral glucose tolerance test, reduction of fasting blood glucose level was observed after 60 minutes of extract and standard administration. At the end of experiment maximum reduction of blood glucose level was seen significantly (p<0.001) in ethanol treated group when compared with diabetic group and (p<0.05) with aqueous treated at a dose of 250mg/kg b.w. The body weight of treated diabetic mice was also seen regained as compared to diabetic control. Serum lipid levels reversed towards near normal and gradual decrease of urine glucose level. The extract treatment also showed a significant increase in the liver glycogen content. The results show that leaves of Eugenia operculata possess significant anti-diabetic activity.

Keywords: Eugenia operculata, Anti-diabetic, Medicinal plant, Streptozotocin, Mice.


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