Mon, 18 Dec 2017

Formulation and Evaluation of Taste Masked Fast Disintegrating Tablet of Tramadol HCl

Bharat A Deshmukh1, Shilpa P Chaudhari1*, Sachin Jagadale1

1.Dept. of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Pimpri Road, Thergaon (kalewadi), Pune- 411033 Maharashtra, India.


ABSTRACT

Orally disintegrating tablet are gaining popularity over conventional tablets due to their convience in administration and suitability for patients. The purpose of the research was to mask the intensely bitter taste of tramadol hydrochloride and to prepare orally disintegrating tablets for achievement of quick onset of action of the drug. Tramadol hydrochloride is an analgesic which has been prove to be efficient in managing relief from pain and including pain after surgery. In the present study an attempt has been made to prepare bitter less orally disintegrating tablet of tramadol hydrochloride using Eudragit EPO as a taste masking agent. Direct compression method was used for preparing tablet & super disintegrating agent like Crosspovidone, Crosscarmellose sodium and sodium starch glycolate were used to prepare blend and evaluated for pre-compression parameter such as bulk density, compressibility, and angle of repose etc. the prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile was found to be satisfactory. It was found that Eudragit EPO being hydrophilic facilitated the increase in the uptake of the saliva thus showing the complimentary action of that superdisintegrant.

Keywords: Tramadol hydrochloride, superdisintegrant, orally disintegrating tablet, Eudragit EPO.


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