Mon, 18 Dec 2017

Physico-Chemical and Instrumental Standardization of the Siddha Herbal Drug Aavaraivithaadhi Chooranam

P.Thenmozhi*1, M.Pitchiah Kumar1, V.Velpandian1, V.Banumathi1

1.Post Graduate Department of Gunapadam (Pharmacology), Government Siddha Medical College, Chennai - 600 106, Tamilnadu,India.


ABSTRACT

Aavaraivithaadhi Chooranam is the classical Siddha medicine used in the treatment of Diabetes mellitus. The aim of the present study was to standardize the Siddha herbal drug formulation Aavaraivithaadhi chooranam by subjecting the drug to various studies like analyzing its organoleptic character, Physicochemical and Instrumental analytical studies like Scanning Electron Microscope (SEM), Energy Dispersing X-Ray Analyser (EDAX) and Fourier Transform Infrared Spectroscopy (FTIR) and the results were noted. The Total Ash value was10.2 %±0.25, Acid Insoluble Ash value was 07.9 %±0.74, Water soluble ash value was 3.4 %±0.08, Alcohol soluble Extractive was 5.78% ±0.39, water soluble ash value was8.18% ±0.58; Loss on drying at 105ºc was 0.0566 %±0.007. The SEM analysis shows the presence of micro particles and its morphology and topography is revealed, EDAX results shows the presence of compounds such as Carbon, Oxygen, Zinc, Magnesium, Calcium, Iron, Potassium, Silica which is responsible for its activity. FTIR analysis revealed the functional groups present through the bonds and stretches which may be the reason for its therapeutic effect. Standardization is an important analytical tool for the identification of the drug. This study brings the effective standardization of the Siddha Herbal formulation through the standard modern analytical studies thus bringing the siddha drug to the next level.

Keywords: Standardization, ash values, SEM, EDAX, FTIR spectroscopy


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