Mon, 18 Dec 2017

Anti-Ovulatory Activity of Siddha Polyherbal Formulation Maavilingathy Mathirai in Female Wistar Albino Rats

B. Sathya1*, V. Velpandian1, M. Pitchiah Kumar1, M. Ramani1, V. Banumathi1

1. Post graduate department of Gunapadam (Pharmacology), Government Siddha Medical College, Chennai, Pin- 600 106, Tamilnadu, India


ABSTRACT

The present study was aimed to evaluate the antiovulatory activity of the Siddha polyherbal formulation Maavilingathy Mathirai in female Wistar albino rats. Female adult mature non pregnant Wistar albino rats weighing 120 to 200 g with at least three regular estrous cycles were administered two doses of 100 and 200 mg/kg orally for 15 days and the control group received 2 ml/kg of CMC solution. On the 16th day all the animals were sacrificed. The effect of the drug on estrous cycle was studied. The proestrous phase of the rats at dose levels of 100, 200mg/kg were found to be highly significant (P < 0.01) when compared with the control. The decrease in median duration of the estrous phase of the rats at dose levels of 100, 200mg/kg were found to be highly significant (P < 0.01) when compared with the control. Metestrous phase was also significantly reduced at dose levels of 100, 200mg/kg as compared to the control and the p value was found to be extremely significant.The results also showed that the p value of ovarian weight at dose levels of 200 mg/kg was found to be highly significant. The cholesterol value of the ovarian tissue at the doses of 100, 200 mg/kg were found to be significant (p<0.05) when compared with the control.Hence the drug proved to have a better antifertility effect on the administration of 100, 200 mg/kg dose levels.

Keywords: antiovulatory, Maavilingathy Mathirai, estrous phase, Wistar albino rats


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