Mon, 18 Dec 2017

Focus on Mucoadhesive Polymer Used in Nasal Drug Delivery System

Bhagyashree A. Pakhale 1*, D M.Shinkar1, R B. Saudagar2

1. Dept of Pharmaceutices, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

2. Dept of Pharmaceutical chemistry. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.


ABSTRACT

Medication activities might be enhanced by creating new medication conveyance frameworks; one such detailing being a mucoadhesive framework. These frameworks stay in close contact with the absorption tissue, the mucous layer, discharging the medication at the activity site prompting expanded bioavailability for both local and systemic impacts. Throughout the last few decades, the application of mucoadhesive polymers in nasal medication conveyance frameworks has picked up enthusiasm among pharmaceutical researchers as a method for advertising dose structure residence time in the nasal cavity and in addition for enhancing closeness of contact with absorptive membrane of the natural framework. Also, the upgraded paracellular absorption after the swelling of the mucoadhesive polymers on the nasal layers gives a critical path to the assimilation of the macromolecules through the nasal cavity. This review explained a few parts of mucoadhesion identified with the nasal medication conveyance framework. On the first check, the theories of the attachment of mucoadhesive polymers to the mucosa epithelium are described. Also, the attributes and application of a few generally utilized mucoadhesive polymers as a part of nasal medication conveyance are introduced. The mucoadhesive polymers have gigantic potential for the conveyance of therapeutic macromolecules, qualities, and immunizations through the nasal cavity with upgraded bioavailability.

Keywords: Mucoadhesion,Mucoadhesive polymers,Nasal medication,Absorption enhancers


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