Mon, 18 Dec 2017

Fast Dissolving Films of Chlorphneiramine Maleate

Bailwal Pragati *1, Juyal Divya1, Dhyani Archana1

1. Himalayan Institute of Pharmacy and Research, Dehradun


ABSTRACT

For more patient compliance there is a great demand for novel dosage form. Fast dissolving drug delivery system offers a solution for the patients who prefer oral route of drug administration without difficulty in swallowing. Fast dissolving films offers the simplest route of administration which is not painful and which do not require water for swallowing. Chlorpheniramine maleate is the First Generation alkyl amine antihistamine and used to relieve symptoms of allergy, hay fever, and common cold. These symptoms include rashes, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. In present study the aim was to formulate and evaluate fast dissolving films of Chlorpheniramine maleate. The films was prepared by solvent casting method, the superdisintegrants Crospovidone (2,4,6,8,10% w/w) and Microcrystalline Cellulose (5,10,15,20,25% w/w) were used in different concentrations with HPMC & PVA as a film forming base. Along with polymers and superdisintegrants the plasticizer PEG, mint flavor and sucrose were used in preparation of films. The formulated films were evaluated for thickness measurement, weight variation, folding endurance, disintegration time, in vitro drug release. It was concluded that the films containing Crosspovidone shows better drug release and less disintegration time as compared to the films containing Microcrystalline Cellulose.

Keywords: Fast dissolving films, Chlorpheniramine maleate, Compliance, superdisintegrants


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