Mon, 18 Dec 2017

Evaluation of Anticlastogenic Activity of Aegle marmelos Leaves Extract Against Cyclophosphamide Using in vivo Micronucleus Assay

Nirmala Gupta*1, Anita Narwariya1, RC Agrawal2, Pushpa Prasad3

1. Dept. of Biotechnology, Institute for Excellence in Higher Education (IEHE), Bhopal (MP)

2. Priyamvada Birla Cancer Research Institute, Satna (MP)

3. Columbia College of Pharmacy, Raipur (CG)


ABSTRACT

Aegle marmelos, a plant having tremendous therapeutic potential, the importance seems largely due to its medicinal properties and all the parts viz. roots, leaves, fruits, bark and seeds are used for curing human ailment. In the present investigation, the anticlastogenic potential of hydromethanolic Aegle marmelos (AM) leaves extract has been evaluated using in vivo Micronucleus assay in Swiss albino mice. Cyclophosphamide (CP), a well known mutagen was given intraperitoneal (i.p.) injection at the dose of 50 mg/kg bodyweight (b.w.). AM leaves extract at the doses of 450, 675, 900 mg/kg b.w. provided protection when given 24 hrs. prior to CP administration. In CP treated animals, a significant induction of micronucleus was recorded and in different AM extracts supplemented groups, a dose dependent significant decrease in CP induced clastogenicity was observed which was statistically significant (p<0.05) as compared to the cyclophosphamide group. It was also observed that Aegle marmelos leaves extract alone could not induce micronuclei formation at the test dose of 450 mg/kg b.w. Thus, the study revealed the antigenotoxic potentiality of AM leaves extract against CP induced micronuclei formation.

Keywords: Cyclophosphamide, Antigenotoxic, Anticlastogenic, Micronucleus, Intraperitoneal.


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