Mon, 18 Dec 2017

Formulation and Evaluation of Orally Disintegrating Tablets of Zolmitriptan Using Direct Compression Method

D.V.R.N.Bhikshapathi*1, M. Shyamala Devi1, V.V.Rajesham1, B. Rajkamal2

1. Vijaya College of Pharmacy, Hayath nagar, Hyderabad, A.P, India.

2. Ganga Pharmacy College, Das Nagar, Borgaon (K), Nizamabad, A.P, India.


ABSTRACT

The present study was an attempt to prepare and evaluate Zolmitriptan 9 different oral disintegrating tablets using superdisintegrants like SSG, Crospovidone and Croscarmellose sodium. Formulations were evaluated for their micromeretic properties and post compression studies and found to be within the limits. Based on the disintegrating time and dissolution studies F9 was found to be best formulation. It was found that the sodium starch glycolate is much more effective than the other super disintegrating agents in the preparation of Zolmitriptan oral disintegrating tablets. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation.

Keywords: Zolmitriptan, ODT’s, SSG, Crospovidone, Croscarmellose sodium.


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