Mon, 18 Dec 2017

Formulation and Evaluation of Sustained Release Metformin Hydrochloride Matrix Tablet Using Natural Polysaccharide

Dharmendra Solanki1*, Surendra kumar Jain2, Sujata Mahapatra3

1. Charak Institute of Pharmacy, Mandleshwar, M.P, India

2. Sagar Institute of Research and Technology, Bhopal, M.P, India

3. Khallikote College, Berhampur,Orissa, India.


ABSTRACT

The aim of this investigation was to develop and optimize Metformin Hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of Metformin Hydrochloride was prepared by wet granulation technique using Tamarind pulp polysaccharide. The polysaccharides obtained after extracted from natural source and evaluated for their colour, viscosity and pH. The prepared tablet was evaluated for their hardness, friability, drug content, In vitro dissolution, swelling studies. In vitro drug release profiles of Metformin Hydrochloride Tablet using Tamarind pulp polysaccharide formulation release of drug from the Tablet exhibited a sustained & controlled pattern over an extended time period. .The tablet formulation TF-1 was found to release the drug of about 95% after 12 hrs, The tablet formulation TF-5 was found to release the drug of about 70% after 12 hrs, thus concluded to have sustained drug release for longer period of time in sustained and controlled pattern when compared to other tablet formulations. Using Higuchi’s Model and the Korsmeyer equation, the drug release mechanism from the sustained release tablets was found to be Anomalous (non-Fickian) diffusion. Compatibility study confirmed that interactions do not exist between the drug and polymer.

Keywords: Metformin Hydrochloride, Tamarind pulp Polysaccharide, matrix tablet, Sustained Release. Swelling index.


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