Mon, 18 Dec 2017

Solvent-Free and Conventional Approach to the Synthesis of Indazole Derivatives through Cyclohexenone and Their Antibacterial Activity

Pranita Sadaphale1*, L.J.Paliwal2, M.B.Bagade2

1. Department of Chemistry, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur-440 033 (India).

2. Department of Chemistry, Seth Kesarimal Porwal College, Kamptee-441 002 (India).


ABSTRACT

Microwave assisted solvent free synthesis of cyclohexenone and indazole derivatives were carried out by chalcones derived from different acetophenones and 1-naphthaldehyde. Structures of the compounds have been characterized by IR, 1H NMR, Mass spectrometry and elemental analysis. All the synthesized indazole derivatives were screened for antibacterial activity and are found to posses moderate to good activity against some species of bacteria.

Keywords: 1-napthaldehyde, chalcones, cyclohexenone, indazole, antibacterial, microwave irradiation.


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