Mon, 18 Dec 2017

Synthesis, Characterization and Biological Activities of Some Novel Heterocyclic Chalcone Derivatives

M Yaseen Mowlana1*, A Jamal Abdul Nasser1, R Karthikeyan1

1. PG & Research Department of Chemistry, Jamal Mohamed College, Thiruchirappalli -20.


ABSTRACT

Chalcones are a category of compounds consisting of two aryl rings linked by an α,β-unsaturated ketone moiety. The synthesized compounds CEA and CMA were evaluated for antimicrobial activity by disc diffusion method. The antibacterial and antifungal activity was evaluated against Moraxella, Enterobacter, Pseudomonas aeruginosa (bacterial strains), Candida albicans, A.niger and Trichophyton (fungal strains) using Erythromycin (for bacteria) and Ciprofloxacin (for fungi) as the standard drugs. The structure of synthesized compounds has been elucidated by IR, 1H, 13C NMR and elemental analysis.

Keywords: Chalcone, antibacterial, antifungal, Nystatin and ciprofloxacin.


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