Mon, 18 Dec 2017

A Review on SEDDS and Solid SEDDS: an Emerging Dosage Forms for Poorly Soluble Drugs

B. Usha Sri*1, Y. Indira Muzib2

1. Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Nalgonda, Telangana- 508284.

2. Sri Padmavathi Mahila Viswavidyalayam, Tirupati, Andhra Pradesh.


ABSTRACT

Oral route is the easiest and most convenient route for drug administration.  The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter and intra subject variability, lack of dose proportionality. It is estimated that 40% of active substances are poorly water soluble. The solubility of such drugs is increased by formulating self emulsifying drug delivery system (SEDDS). Self emulsifying drug delivery systems have gained exposure for their ability to increase solubility and bioavailability of poorly water soluble drugs. SEDDS are isotropic mixtures of oil, surfactants, solvents and co-solvents/surfactants, which emulsify to produce fine oil-in-water emulsions upon gentle agitation. SEDDS typically produce emulsions with a droplet size between 100–300 nm. Solid SEDDSs are being developed from liquid/semisolid SEDDS mainly by adsorption on solid carriers, spray drying, lyophilization, melt extrusion, and nanoparticle technology. This review focuses on newer approaches for development of SEDDS and Solid SEDDS.

Keywords: Self emulsifying drug delivery system, Co-solvents, surfactants, Solid SEDDS.


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