DOI: 10.21276/ajptr
Fri, 22 Mar 2019

The Degradations Routes of Ramipril and Its Products

Guilherme Davi Aschar1*, Laura Oliveira2, Paulo Cesar Pires Rosa3

1.Master´s in Biosciences and Bioactive Products Technology, Universidade Estadual de Campinas, UNICAMP, Instituto de Biologia, Campinas, SP, Brazil.

2 .Universidade Estadual de Campinas, UNICAMP, Instituto de Biologia, Campinas, SP, Brazil.

3 .Universidade Estadual de Campinas, UNICAMP, Faculdadede Ciências Farmacêuticas, Campinas, SP, Brazil. 


Ramipril is a prodrug of the active metabolite ramiprilat, it inhibits angiotensin-converting enzyme and consequent raise in blood pressure. Its pharmacologic effect aids the treatment of hypertension, congestive heart failure and reduces mortality in post myocardial infarction patients. As for other drugs, Ramipril might degrade upon storage and compromise the quality, efficacy and safety of the product. In order to avoid deterioration, it is important to characterize the degradation products and source of stress (temperature, water content, oxidizers, etc). This review aims to summarize the data concerning the subject and serve as a guide for further studies.

Keywords: Ramipril, Impurities, Stress testing, Degradation Pathways

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