Mon, 18 Dec 2017

The Degradations Routes of Ramipril and Its Products

Guilherme Davi Aschar1*, Laura Oliveira2, Paulo Cesar Pires Rosa3

1.Master´s in Biosciences and Bioactive Products Technology, Universidade Estadual de Campinas, UNICAMP, Instituto de Biologia, Campinas, SP, Brazil.

2 .Universidade Estadual de Campinas, UNICAMP, Instituto de Biologia, Campinas, SP, Brazil.

3 .Universidade Estadual de Campinas, UNICAMP, Faculdadede Ciências Farmacêuticas, Campinas, SP, Brazil. 


ABSTRACT

Ramipril is a prodrug of the active metabolite ramiprilat, it inhibits angiotensin-converting enzyme and consequent raise in blood pressure. Its pharmacologic effect aids the treatment of hypertension, congestive heart failure and reduces mortality in post myocardial infarction patients. As for other drugs, Ramipril might degrade upon storage and compromise the quality, efficacy and safety of the product. In order to avoid deterioration, it is important to characterize the degradation products and source of stress (temperature, water content, oxidizers, etc). This review aims to summarize the data concerning the subject and serve as a guide for further studies.

Keywords: Ramipril, Impurities, Stress testing, Degradation Pathways


[PDF]  Viewed: 1650  Downloaded: 223
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter