Sat, 16 Dec 2017

A Review on Gastroretentive Floating Drug Delivery System

Audumbar Digambar Mali1*, Ritesh Suresh Bathe1

1. Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.


ABSTRACT

One of the most feasible approaches for achieving prolonged and predictable drug delivery profiles in gastrointestinal tract is to control the Gastric Residence Time (GRT) using gastro retentive dosage forms (GRDFs) that offer a new and better option for drug therapy. Oral delivery of drugs is by far the most preferable route of drug delivery. Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. In order to overcome these drawbacks novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time were discovered and they successfully exists today as gastro retentive dosage forms, in academic and industrial research groups. The objective of our review is to compile the recent advancements and literatures regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recent developments of Stomach Specific FDDS are discussed. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.

Keywords: Floating drug delivery, Buoyancy, Oral drug delivery, Gastro retention, Effervescent, Gastric emptying time etc.


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