Sat, 16 Dec 2017

SclerocaryaBirrea Oil ModulatesHuman T-Lymphocyte Differentiation

Eugène S. Attakpa1*, Alphonse Sezan1, Lamine Baba-Moussa2, Bialli Seri3, Messanvi Gbéassor4, NaimAkhtar Khan5

1. Laboratoire de Biomembranes et SignalisationCellulaire, Département de PhysiologieAnimale, Faculté des Sciences et Techniques 01 BP : 4521 Universitéd’AbomeyCalaviCotonou (Rép. du Bénin).

2. Laboratoire de Biologie et de TypageMoléculaire en Microbiologie, Faculté des Sciences et Techniques/Universitéd’Abomey-Calavi, 05 BP 1604 Cotonou (Rép. du Bénin).

3. Laboratoire de Neurosciences, Unité de Formation Biosciences 22 BP 582 Abidjan 22 Université de Cocody-Abidjan (Rép. de Côte-d’Ivoire).

4. Centre de Recherche et de Formation sur les PlantesMédicinale, Département de PhysiologieAnimale, Faculté des Sciences, Université du BéninBP : 1515 (Lomé-Togo).

5. UnitéPropre de Recherche de L’EnseignementSupérieur EA 4183 Lipides et SignalisationCellulaire, Faculté des Sciences de la Vie, Université de Bourgogne-Dijon (France).


ABSTRACT

Sclerocaryabirrea (A. Rich.)Hochst. (Anacardiaceae) is one of the plants that played a role in feeding people in ancient times. English name Marula, is a savannah tree, belonging to the family Anacardiaceae, with a plum-like pale yellow fruit of 3–4 cm in diameter with a juicy mucilaginous flesh. Sclerocaryabirrea is deciduous and mainly dioecious, although there have been reports of monoecioustrees.The oil is extracted from the kernels that contain between 65% oil.This oil is composed with large amount of fatty acids which includes oleic acid (80-85%), linoleic acid (6.0-8.0 %), alpha-linolenic acid (0.2-0.9 %), palmitic acid (10-14%), stearic acid (7.0-9.0 %), arachidonic acid (0.5-0.8 %). Further tocopherols (26mg/100g), flavonoids are also found in Sclerocaryabirrea oil. Our results show that Sclerocaryabirrea oil exerted the most potent immunosuppressive effects on T cell proliferation and IL-2 mRNA expression.Sclerocaryabirrea oil-induced secretion of IL-4 by T-cells.The densitometric analysis of western blots revealed that Sclerocaryabirrea oilinhibited the phosphorylation of the three MAP kinases in T-cells.

Keywords: Fatty acids CD3 Jurkat T-cells Oil Sclerocaryabirrea.


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