DOI: 10.21276/ajptr
Fri, 22 Mar 2019

Synergistic/Antagonistic Interactions of Antibiotics and Hot Aqueous Tinospora Cordifolia Extracts

Rashmi Zankyani1*, M. G. Roymon1

1. Microbiology Research Centre, Dept. of Microbiology and Biotechnology, St. Thomas College, Bhilai-490006 (C.G.), India.


Present study analyzes antibacterial and synergistic potential of different parts of Tinospora cordifolia hot aqueous extracts against three environmental isolates and three MTCC reference strains of K. pneumoniae, E. coli and P. aeruginosa. Antibacterial activity was observed by agar dilution method in triplicates. Synergistic potential of extracts was observed with seven different antibiotics named as Ceftiaxone (CTR), Kanamycin (K), Gentamycin (GEN), Chloramphenicol (C), Cefotaxime/Cephotaxime (CTX), Tetracycline (TE) and Nalidixic Acid (NA). Results revealed that no extracts shows any antibacterial activity, while synergistic activity was observed with various antibiotics with plant extracts. This concluds that plant extract contains antibiotic resistance inhibitor compound in it. Results show maximum synergistic activity with chloramphenicol against P. aeruginosa with all four aqueous extracts. While no synergistic or antagonistic activity was observed against K. pneumoniae with hot aqueous fruit and leaf extract with any antibiotics used. Antagonistic activity of hot aqueous leaf extract was observed with Ceftiaxone against E. coli followed by Cefotaxime against MTCC K. pneumoniae. While synergistic activity was observed with Chloramphenicol against P. aeruginosa, MTCC P. aeruginosa and Ceftiaxone against P. aeruginosa. It will be a great achievement for the researchers to test different combination of antibiotics and plant extracts without any confirmatory consideration of their individual effect in-vitro. This kind of synergistic work can lead to great evolution in pharmaceutical industries.

Keywords: Synergism, antagonistic, antibiotics, K. pneumoniae, E. coli, P. aeruginosa.

[PDF]   Viewed: 1007   Downloaded: 79
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter