Mon, 18 Dec 2017

Oxyntomodulin, Obestatin and Leptin Potential Weight Reducing Agents: a Review

Shriram Bairagi1*, M.A. Hameed Sadiq1, Mohammed Shoaib Patel1, Rahul B. Ushir1, Suraj V. Patil1, Ramesh Choudhary1

1. Ideal College of Pharmacy and research, Kalyan (E), 421306, Maharashtra, India.


ABSTRACT

As obesity remains the center of concern from many decades but yet there is no exact treatment, mostly you have to prefer the surgical method such as gastric bypass, which remains the only therapeutic treatment and the anti-obesity pharmacotherapy remains very limited therefore the priority is to discover or develop more potent drugs. The only potential strategy is to achieve weight loss it can be done by either reducing energy intake or by stimulating anorexigenic signals or by blocking orexegenic signals and to increase energy expenditure. This can be achieved by stimulating the Oxm, peptide PYY, GLP, GLP-1 receptor, and fat cells derived hormone like Leptin and Obestatin these reduces obesity by reducing food intake as seen in mice and humans by stimulating satiety signals, and by regulating the glucose homeostasis, by secreting glucose dependent insulin.

Keywords: Oxyntomodulin, Obestatin, Leptin, anti-obesity


[PDF]  Viewed: 706  Downloaded: 201
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter