Mon, 18 Dec 2017

Formulation and Evaluation of Floating Matrix Tablets of Dipyridamole

Kiran Kumar1*, P. Srikanth1, M. Ajitha2, Madhusudan Rao Y1

1. Department of Pharmaceutics Vaagdevi Institute of Pharmaceutical Sciences. Bollikunta, Warangal – 506005, Telangana State. India

2. R&D Cell JNTUH kukatpally Hyderabad-500085.


ABSTRACT

Single unit floating effervescent matrix tablets of Dipyridamole were successfully prepared with hydrophilic polymers like HPMC K4M , HPMC K15M and HPMC K100M with 10% NaHCO3 by Simple direct compression method with drug: polymer ratio of 1:1.5,1:2,1:2.5:1.3. FT-IR studies were conducted between drug, polymer and various excipients used in the formulations. Evaluation parameters of powder blend like Hausner’s ratio, Compressibility index, Angle of repose were carried out and results showed that the powder has good flow properties. Formulated tablets gave satisfactory results for various evaluation parameters like tablet hardness (5-6 Kg/cm2), weight variation (±10%), Friability (<0.9%), content uniformity (90%-110%), thickness (4-5mm) in vitro buoyancy properties and in vitro drug release. The floating lag time was found to be less for the formulations FS2, FS5, with 50sec, 48sec, respectively. Even the total floating time was found to be more than 12hrs for FS2, FS5, formulations with more than 90%drug release upto 12hrs. The swelling studies were carried for 24 hrs. The results indicate that the selected polymers were of swellable type and HPMC K4M has marginally more swellability than HPMC K15M and HPMC K100M matrices.  In vivo radiographic studies in fed condition the single unit matrix tablets (FS5) showed a gastric residence time of more than 6hrs. Indicated that the tablets remained in the stomach for 6hrs, which indicates the increase in the GRT is due to floating and swelling principle.

Keywords: Dipyridamole, Radiographic Studies, Hydrophilic Polymers, Floating Effervescent Matrix Tablets.


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