Mon, 18 Dec 2017

Morin Hydrate Prevents Neurodegeneration in 3-Nitropropionic Acid Induced Huntington’s Disease

Anagha C. Rao1, Varsha M. Shende*1

1. Department of Pharmacology, STES’s Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-411041, Maharashtra, India.


ABSTRACT

The present study was designed to investigate the neuroprotective effect of a flavonoid Morin Hydrate in 3-nitropropionic acid induced model of Huntington's disease.3-Nitropropionic acid was used to induce symptoms similar to that of Huntington’s disease in male wistar rats. Rats were treated with Morin (50 mg/kg and 100 mg/kg) for 14 days. Body weight, brain weight, behavioural parameters, biochemical parameters were assessed and brain samples were sent for histopathology.3-nitropropionic acid administration for 14 days significantly induced symptoms such as reduced body weight, impaired gait, locomotor activity, muscle grip strength and also caused oxidative stress in striatum. The treatment with Morin 50 mg/kg was less effective as compared to that of Morin 100 mg/kg. Morin (100 mg/kg)showed slightly reduced oxidative stress as well as motor coordination deficits. Histopathology results also revealed reduced neuronal degeneration in Morin (100 mg/kg) samples as compared to Huntington control (HC) rats. This evidence suggest flavonoid Morin might have protective effect against 3-Np induced huntington’s disease or disease like symptoms, and further studies on higher doses are needed to explore the usefulness of flavonoid Morin in HD.

Keywords: Huntington’s disease, 3-Nitropropionic acid, Morin Hydrate, Antioxidant, Neuroprotective


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