DOI: 10.21276/ajptr
Sat, 25 May 2019

Development of Novel Azobenzene Diacetic Acid Allyl Ester Polymers for Colon Specific Drug Delivery

Prasad Gorde1*, Suyash Akole1, Ashok Pingle1, Sanjay Wagh1

1. Department of Pharmaceutical Chemistry, MVP Samaj’s college of Pharmacy, Gangapur Road, Nashik (MS)-422002, INDIA.


A novel polymer based on azobenzene-4,4’-diacetic allyl ester as core linker polycondensated with methyl methacrylate and n-butyl methacrylate was conveniently synthesized for the purpose of targeting colonic drug delivery. The cross linker was characterized by infrared spectroscopy, nuclear magnetic resonance and mass spectroscopy. The synthesized polymers (PMB) showed good film forming. Comparative study of synthesized polymers was done using In-vitro drug release pattern of budesonide from polymer coated capsule formulation in colonic media. Budesonide capsules coated with PMB1:1:2: B and PMB1:1:3: B showed maximum drug release in colon in a sustained release manner.

Keywords: colon specific drug delivery, azoreductase, diazo linker, allyl ester, budesonide.

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