Mon, 18 Dec 2017

Formulation and Evaluation of Sustained Release Matrix Tablets of Cefadroxil by Using Direct Compression Method

Madhavi C1*, Ramesh Y1, Deepthi A1, Gnana Prakash. K1, Gobinath. M1, Sankar Rao. K1

1. Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur(M), SPSR Nellore (Dt) 524346, A.P., India.


ABSTRACT

Cefadroxil is a first generation cephalosporin antibiotic intended for oral administration. In the Present investigation, an attempt has been made to increase the therapeutic efficacy to reduce the frequency of administration and to improve the patient compliance by developing the sustained release matrix tablets of Cefadroxil by using direct compression method. Excipients like Xanthun gum, HPMC K 15 M, PVP K 30 are used as matrix polymers. MCC used as diluents, magnesium stearate as lubricant, and talc act as a glidant. The different excipients were tested for their compatibility with the drug Cefadroxil by using FTIR and DSC, which revealed that there was no chemical and physical interaction occurred. Then the Preformulation parameters like bulk density, tapped density, compressibility index, and Hauser’s ratio were analyzed for prepared powder before compression. The thickness of best formulation CF9 is 3.5mm, hardness of best formulation CF9 is 3.6kg/cm2, friability of best formulation CF9 is 0.66%, weight variation of best formulation CF9 is 499±0.39.The In-vitro drug release were performed in the USP Apparatus (basket) using 0.1 N HCL as dissolution media at 50 rpm speed. The sample was done at periodic intervals of 1hr, 2hr, 3hr, 4hr, 5hr, and 6hrs and was replaced with equal volume of dissolution media to maintain the sink condition. The best In-vitro release shown by formula CF9 that is 95% .The results indicate that the selected formulation was stable during the period of accelerated stability studies. The optimized formulation CF9 compared with the marketed sample Cetil-500mg. Marketed sample in-vitro drug release is 98.85%. All evaluated formulations results were found to be satisfied.

Keywords: Cefadroxil, sustained release matrix tablets, xanthan gum, HPMC K15M, PVP K 30.


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