Mon, 18 Dec 2017

Hepatoprotective and antioxidant activities of methanol extract of Michelia champaca on carbon tetra chloride induced liver damage

Raja Sundararajan1*, Ravindranadh Koduru1

1. GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, India.


ABSTRACT

Michelia champaca, a healthful plant and it's normally utilized in people medication to treat varied diseases. The aim of the study was to evaluate the hepatoprotective & invivo antioxidant activities of Michelia champaca against carbon tetrachloride induced liver injury in rats. The methanol extract of Michelia champaca at dose of 250 and 500 mg/kg were administered orally once daily for seven days. Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin (TB), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total protein (TP) were estimated from serum. In-vivo antioxidant activity of methanol extract of Michelia champaca was evaluated by various assays including catalase (CAT), superoxide dismutase (SOD), reduced glutathione, glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels in liver tissues. Histopathological examination of the liver sections was carried out to support the induction of hepatotoxicity. The results of the study indicated that, methanol extract of Michelia champaca 500 mg/kg showed a major decrease in SGPT, SGOT, TB, ALP, LDH levels that were all elevated within the carbon tetra chloride treated group. The Michelia champaca extract showed considerably redoubled the degree of CAT, SOD, GSH, GPx, GRD and reduce the degree of MDA. Michelia champaca leaves extract therapy also protective effects against histopathological alterations. From the above study it can be concluded that methanol extract of Michelia champaca had hepatoprotective & antioxidant activities against carbon tetra chloride induced hepatic damage in experimental animals.

Keywords: Michelia champaca, carbon tetra chloride, hepatoprotective, antioxidant activity.


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