DOI: 10.21276/ajptr
Mon, 27 May 2019

Design and Characterization of Transfersomal Loaded Gels for Transdermal Drug Delivery of Fluvastatin Sodium

V.Lakshmi Narasaiah*1, P.Padmabhushanam2, V.Sai Kishore3

1.Department of Pharmaceutics, Dr SGIPS, Markapur, Prakasam, A.P

2.Department of Pharmaceutical Analysis, Monad University, Hapur, U.P

3.Department of Pharmaceutics, Bapatla College of Pharmacy, Bpatla, Guntur, A.P


In the present study, an attempt was made to develop the transdermal drug delivery systems of Fluvastatin sodium using transfersomes incorporated in a gel, which will control the release of drug, increasing the bioavailability of the drug and thus decreasing the dosing frequency of the drug.  It was designed by encapsulating the drug in various transfersomal formulations composed of various ratios of Soya Lecithin: Span 80 or Tween 80 or sodium deoxycholate. The transfersomes were prepared by rotary evaporation sonication method. Lipid:surfactant ratio of 90:10 is  found to be more effective when compared to other ratios . Experimental results of the present study showed that deformable lipid vesicles improve the transdermal delivery, prolong the release, and improve the site specificity of the Fluvastatin sodium. The drug diffusion studies showed that the prepared transferosome vesicle follows zero order kinetics and mechanism of drug diffusion follows peppas model.

Keywords: Transfersomes, Anti-hyperlipidemic, Controlled release, Lipid, Surfactant.

[PDF]   Viewed: 876   Downloaded: 83
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter