Sat, 16 Dec 2017

Anti-asthmatic activity of Hydro Alcoholic Extract of Ficus trichopoda Bak. Leaves in Guinea Pig

Randrianavony Patricia*1, Tsirimaminiaina Hery Lalao Jorosoa1, Quansah Nat2, Randrianjafitrimo Nicolas1, Randimbivololona Fanantenanirainy1.

1  Laboratoire de Pharmacologie Générale, de Pharmacocinétique et de Cosmétologie, Faculté des Sciences Antananarivo, Université d’Antananarivo, MADAGASCAR.

2  SIT (Study Abroad Summer Program: MADAGASCAR Traditional Medicine and Health Care Systems).


ABSTRACT

The anti-asthmatic activity of Ficus trichopoda was studied in guinea pigs in vivo and in vitro using the isolated guinea pig trachea. 33%, 66% and 100% of the animals treated with the hydroalcoholic extract of Ficus trichopoda at doses 100mg/kg, 200mg/kg and 300mg/kg respectively, were protected from spasm of the air way caused by pulverization of 5% histamine aerosol. In vitro, the isolated guinea pig trachea contracted with histamine at 10-4 M was relaxed with the extract with an EC50 of 65.75µl/ml. The pre-incubation of the isolated trachea in the bath containing the extract at concentrations of 100µl/ml and 200µl/ml increased the EC50 of histamine from (1.10. ± 0.025) 10-6 M to (5.95±0.05) 10-6 M and (1.49±0.01) 10-5M respectively. The maximal contraction provoked by histamine, however, remained unchanged. These effects could be caused by the alkaloids and/or flavonoids present in the extract.

Key words: Ficus trichopoda, asthma, guinea pig


[PDF]  Viewed: 392  Downloaded: 65
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter