Sat, 16 Dec 2017

Burn skin pathogens: Isolation, identification and antimicrobial activity pattern against pyrazole derivatives

Essa Ajmi Alodeani1, Mohammad Arshad1* Mohammad Asrar Izhari1*

1. College of Medicine Al-Dawadmi, Shaqra University, Kingdom of Saudi Arabia.


ABSTRACT

Fifty pus samples were collected from burn patients with age ranging 10-55 years with invasive wound infection using sterile cotton swabs. Pure culture were isolated, maintained, preserved and subjected for morphological characterization, accomplished by studying the colony characteristics on different culture plates followed by simple, negative and Gram staining. The cultures then also subjected for biochemical characterization performing various biochemical tests Recovered pathogens were mostly Gram negative. The most common causative agent was found to be Pseudomonas aeruginosa (39.5%), followed by Staphylococcus aureus (25.5%), Acinetobacter baumannii (10%), Klebsiella spp (4.2%), Proteus vulgaris (3.5%) and Escheritia coli (2%). All the previously synthesized compounds were tested on all the isolated pathogens using disc diffusion method and Ciprofloxacin was used as standard drug. The results revealed that out of five, three compounds (1-3) were found to possess significant antimicrobial potential against all pathogens and compounds 4, 5 were also exhibited good activity against E. coli.

Keywords: Burn skin pathogens, pyrazole, antimicrobial activity


[PDF]  Viewed: 539  Downloaded: 88
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter