Sat, 16 Dec 2017

Anti-ulcer Activity of Hydro Alcoholic Extract of Acridocarpus excelsus a. Juss Leavesin Rat

Randrianavony Patricia1*, Raharivelonina Eddie Albertine1, Randrianjafitrimo Nicolas1, Quansah Nat2, Randimbivololona Fanantenanirainy1

1. Laboratoire de Pharmacologie Générale, de Pharmacocinétique et de Cosmétologie, Faculté des Sciences, Université d’Antananarivo, MADAGASCAR.

2. SIT (School for International Training) Study Abroad / World Learning Summer Program: Madagascar Traditional Medicine and Health Care Systems, Antananarivo, MADAGASCAR


ABSTRACT

The anti ulcer activity of the hydro alcoholic extract of the leaves of Acridocarpus excelsus was studied in vivo using WISTAR rats. This study investigated the extract’s effect on gastric ulcer induced by indomethacin orally administered at the dose of 30mg/kg, acid secretion by pylorus ligation and mucus secretion. The results obtained showed that ulceration provoked by the indomethacin on the gastric mucosa surface was reduced from 13.12 ± 0.96 mm2 found inthe control group to 8.15± 0.12 mm2, 2.87 ± 0.41 mm2  and  1.25 ± 0.05 mm2 respectively in the rats treated with the extract at doses 150 mg/kg, 300 mg/kg and 600mg/kg (p<0.05). After pylorus ligation, the gastric content pH was 2. 01 ± 0. 07 for the control group; 3.67 ± 0.14, 5.82 ± 0.04 and 6.82 ± 0.27 respectively for the rats that received the extract at doses 150 mg/kg, 300 mg/kg and 600mg/kg (p<0.05). The mucus secretion of the control group was 18.06±1.02 mg but was 25.60±0.35 mg, 30.00±0.28 mg and 40.80±0.55 mg respectively in the groups that received the extract at doses 150mg/kg, 300mg/kg and 600mg/kg. These results show the anti-ulcer activity of Acridocarpus excelsus leaves. The extract of the leaves protected the gastric mucosa against damages induced by indomethacin, decreased gastric acidity by increasing the pH of the gastric content and increased mucus production.

Keywords: anti-ulcer, Acridocarpus excelsus, rats.


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