Sat, 16 Dec 2017

Comparitive Evaluation of Three Granulation Processes for Antidiabetic Drug of Gliclazide by Using Design of Experiment

Gangapuram Sushma1*, Vinay Umesh Rao1.

1. Indutrial Pharmacy, MallaReddy College of Pharmacy, Maisammaguda, Secunderabad.


ABSTRACT

In the present study compared and evaluated the three granulation process for controlled release antidiabetic drug of Gliclazide. The effect of three different polymers on the in-vitro dissolution profiles of Gliclazide controlled release tablet was studied. Later combinations of polymers were used and the tablets were prepared by using wet, dry and MADG (Moisture Activated Dry Granulation) process. The study was carried out using full factorial designs of experiments. The release rate of 5 to 6 mg%/ hour was targeted and the effect of the polymers on drug release over 24 hours was evaluated. The DOE experiments have shown that when the combination of polymer is used, the total polymer concentration should be in a narrow range of 32.4% w/w to 37.5% w/w in order to achieve the target dissolution profile for Gliclazide. The effect of three granulation process on the tablet properties and drug release were studied. Wet granulation and MADG process were compared. Finally MADG process is showing better results when compared with other process.

Keywords: Gliclazide, MADG (Moisture Activated Dry Granulation), Design of Experiments (DOE).


[PDF]  Viewed: 344  Downloaded: 78
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter