Sat, 16 Dec 2017

Gastro-Protective Potential of Trichosanthes Dioica in Experimental Animals

Devansh Mehta1*, Anuj Kumar Sharma2

1. Kharvel Subharti College of Pharmacy,  Subharti university. Meerut. U.P. 250110

2.Translam Institute of Pharmaceutical Education and Research, Meerut, UP. Pincode: 250001.


ABSTRACT

Ulcer is tissue erosion, either on skin or inside the body, for e.g. lining of gastrointestinal tract. The diverse causes for ulcer development range from, Genetic factors to Physiological/ Environmental factors. Helicobacter pylori recently found to be responsible for majority of peptic ulcer cases. Peptic ulcer diseases are extremely common in developing and developed countries with annual incidence of 1 to 3 per 1000th of the population. PUD is an important cause of morbidity and health care costs; estimates of expenditures related to work loss, hospitalization, and outpatient care are $5.65 billion per year in US. It affects 1 in 10 men & 1 in 15 women in Europe. Due to side effects from conventional drug therapy and non-specificity of therapeutic choices, there is inclination towards Traditional medicines with low cost and low adverse effect incidences. Many photochemical substances have been found to be effective against pathogenic factors responsible for ulcer formation and its severity. Alkaloids, Flavonoids, Terpenoids, & Tannins have been researched to possess potent Gastroprotective activities. Glycosidal components have been found effective against Helicobacter pylori gram negative strains. Trichosanthes dioica (Roxb.) found in flora and fauna of Uttar Pradesh have high concentrations of terpenoids, flavonoids, cucurbitacins, which have been researched for having anti-inflammatory and wound healing activities. The present study clearly shows the effectiveness of Trichosanthes dioica (Roxb.) in having Gastroprotective activity. This gives clear indication that Trichosanthes dioica shall be researched upon to bring effective drug in market against ulcer diseases.

Keywords: Trichosanthes dioica, Peptic Ulcer Diseases (PUD), Gastroprotective potential, Anti-ulcer drugs, Trichosanthes species, Methonolic extract of Trichosanthes dioica (MeTD)


[PDF]  Viewed: 1019  Downloaded: 159
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter