Mon, 18 Dec 2017

Solid Self Nano-Emulsifying Drug Delivery Sysytem: A Review

Gadge Prashant B*1, Salunkhe K.S1, Chaudhari S.R1, Nehe P.T1, Gade A. V1, Sanjay Harale2

1. Department of pharmaceutics, Amrutvahini College of pharmacy, Sangamner, Ahmednagar.

2. Watson pharma pvt. Ltd. Goa.


ABSTRACT

Self nanoemulsifying drug delivery (SNEDDS) is used for drugs which exhibit low water solubility. Dissolution is the rate limiting factor for these drugs. SNEDDS are capable of improving the bioavailability substantially of such drugs. They are formulated by utilizing an oil phase, surfactant and a co-surfactant. This formulation forms nano emulsion (O/W type) on contact with aqueous body fluids i.e. gastric juices when administered orally. Solid SNEDDS (s- SNEDDS) can also be formulated in the form of tablet which shows greater advantages. With recent and potential future developments, this technology will continue to enable novel applications in drug delivery and overcome limitations associated with the delivery of poorly water soluble drugs, mainly those belonging to BCS class-II and class-IV.

Keywords: Self nanoemulsifying drug delivery system (SNEDDS), oil phase, surfactants, cosurfactants, Pseudo ternary phase diagrams.


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