Mon, 18 Dec 2017

Review on Fundamentals of Dendrimers

Harshata Bhaidas Saindane1*, Swati Gokul Talele1, Ghanashyam Chaudhari1, Nilesh Chaudhari1, Pooja Manohar Arane1, Priti Rajendra Jadhav1

1. Sandip Institute of Pharmaceutical Sciences, Mahiravani, Nashik, Maharashtra, India.


ABSTRACT

This review gives concise information about physico-chemical properties, synthetic strategies, characterization and possible application of Dendrimers in drug delivery. Dendrimers also known as arborols. They are radially symmetric molecules having nano size with well-defined, homogeneous and monodisperse structure consisting of tree-like arms or branches. Due to their unique architecture these have improved physical and chemical properties. They are having terminal groups, due to which these show high solubility, miscibility and reactivity. The major applications of Dendrimers are: Gene and oligonucleotide delivery, Targeting of anticancer chemotherapy. Their compatibility with DNA, heparin and polyanions make them more versatile.

Keywords: Dendrimers, PEGylated dendrimers, PPI Dendrimer, PAMAM Dendrimer, PAMAMOS Dendrimer.


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