Mon, 18 Dec 2017

Medicated Chewing Gum: A Recent Trend of Drug Delivery System

Abhilash Mund1*, ByomakeshPanda2, Shakti Prasad Mund3

1. Formulation Research & Development, Alkem Laboratories Ltd., Taloja- 410208, Mumbai, Maharashtra, India

2. Formulation Research & Development, Inventia Healthcare Pvt. Ltd., Thane- 400604, Maharashtra, India

3. Formulation Research & Development, Centaur Pharmaceuticals Pvt. Ltd., Pune- 411057, Maharashtra, India


ABSTRACT

From the past few decades scientific and technological advancement have been made in the pharmaceutical research and development of oral drug delivery system. Medicated chewing gum (MCG) has drawn attention to the researcher as potential drug delivery system. MCGs are the non-dissolving intraoral dosage form intended for local treatment of diseases of the oral cavity as well as systemic delivery after absorption through buccal mucosa in which the continuation of drug release depends up on masticatory activities. A special in-vitro apparatus was designed and constructed for release testing of MCGs which is official in European Pharmacopoeia. It is an excellent and convenient drug delivery system for self-medication and can be administered discreetly without water. Consequently at present chewing gum is a convenient drug delivery system, which is appropriate for a wide range of active substances. It is very likely that MCGs will be a common drug delivery system and could be a commercial success in imminent future. Purpose of this review article is to discuss the advantage and drawback, methods of preparation, evaluation, and release of drugs, factors affecting release, safety aspects and development with respect to the medicated chewing gums.

Keywords: Medicated chewing gums (MCGs), Oral drug delivery system, In-vitro apparatus, Systemic delivery.


[PDF]  Viewed: 1309  Downloaded: 189
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter