Mon, 18 Dec 2017

Gastro-Protective Effect of Ethanolic Extract of Artocarpus Altilis (Breadfruit) on Alcohol Induced Acute Ulcer Model in Albino Wistar Rats

Ajah Austin A1*, Olorunfemi O Joyce1, Onasanwo A. Samuel2

1. Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences,  University of Port Harcourt, Choba, Port Harcourt, Nigeria.

2. Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine,University of Ibadan, Ibadan, Nigeria.


ABSTRACT

The study was designed to investigate the gastro protective effects of fruit extracts of Artocarpus altilis (Breadfruit), using alcohol induced acute ulcer model. The extracts were administered at doses100mg/kg, 200mg/kg and 300mg/kg. 10mg/kg of Omeprazole was used as a reference standard. The parameters used for this were percentage of animals with gastric ulcer (UP), ulcer index (UI) and percentage protection of ulcer (%P). The percentage of animals with ulcer was lowest in both the groups treated with 300mg/kg (16.67 ± 0.004) of extract and those treated with omeprazole (16.67 ± 0.004). While the animals in control group and those treated with 100mg/kg of extract had the highest percentage of animals with ulcer (100.01 ± 0.005). The gastro protective activity was accessed by determining and comparing the ulcer index in the test group with that of the control group. Animals pretreated with Artocarpus altilis extract showed significant reduction in ulcer index in a dose dependent manner when compared to the control group having an ulcer index of 11.51 ± 0.005 when treated 100mg/kg of extract, 3.66 ± 0.004 & 1.83± 0.004 for 200mg/kg & 300mg/kg of extract respectively. The gastro protective effect of 300mg/kg had the same potency as the standard drug Omeprazole. The administration of 100mg/kg, 200mg/kg, 300mg/kg and Standard drug (Omeprazole) reduced Gastric lesions by 9%, 71%, 85.5% and 85.5% respectively. The results suggest that the extract possesses significant protective properties against ulcer in albino rat compared to the control group.

Keyword: Artocarpus altilis, Omeprazole, gastro protective, gastric ulcer, ulcer index.


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