DOI: 10.21276/ajptr
Fri, 24 May 2019

A Comparative Photostability Study of Flagyrid, Metronidazole and Metrogyl Intravenous Infusion Brands Registered in Sudan

Zuheir Osman1, Dhia E.Elhag*2, Azza H.Suliman2, Mohammed Jalal Almansour3

1. Department of Pharmaceutics, Faculty of pharmacy, University of khartoum, Sudan.

2. Department of Pharmaceutics, Faculty of pharmacy, University of Medical Science and Technology, Sudan.

3. Department of Pharmaceutics, Faculty of pharmacy, National University – Sudan.


Metronidazole 2-(2-methyl-5-nitro-1H-imidazole-1-yl) ethanol is a synthetic nitroimidazole derivative of antibacterial and antiprotozoal activity. It has different dosage forms. The stability of the Metronidazole intravenous of three different brands was studied in order to investigate the kinetics of photodegradation of this drug using a UV/ Vis spectroscopy. The degradation was carried out by the use of short (254 nm) and long UV (352 nm) lamps. The kinetics parameters of reaction order and the rate constants of the degradation were determined for the three brands products.  The degradation process was found to follow first-order kinetics. The present study also reveals that the drug is light-sensitive. Thus, appropriate light protection is recommended during the storage and handling of metronidazole products. The study highlighted the fact that there is a correlation between the radiation intensity and degradation of metronidazole (photodegradation), i.e. as the radiation energy becomes stronger, the degradation rates increases. Furthermore, the rate of degradation was found to follow pseudo-first order reaction. It was also found that as the exposure time of these drugs to radiation increased the degradation was amplified. For all three brands were used in the investigation, the average rate of degradation when using long UV irradiation, and short UV radiation as stress factors were found to be,-0.0061 day-1 and -0.026 day-1 respectively. The obtained results show that UV/vis spectroscopy is satisfactory technique at the determination of metronidazole degradation kinetics in e intravenous products.

Keywords: UV/Vis spectroscopy, stability, kinetic of degradation, metronidazole.

[PDF]   Viewed: 2087   Downloaded: 178
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter